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Med Check
Key Ubiquilin Study Findings
Psychiatric News
Volume 46 Number 19 page 21-21

  • The ubiquilin gene (UBQLN1), which encodes the ubiquilin-1 protein, has been genetically linked to late-onset Alzheimer's.

  • Ubiquilin-1 protein levels are significantly decreased in the brains of late-onset Alzheimer's patients.

  • Diminished ubiquilin function may be a common denominator in AD progression.

  • Ubiquilin's interaction with amyloid precursor protein (APP) shows characteristics of a chaperone-client relationship, in which ubiquilin interacts transiently with APP to prevent irreversible aggregation and processing of APP that could lead to amyloid plaque formation. 21_3.inline-graphic-1.gif

  • The ubiquilin gene (UBQLN1), which encodes the ubiquilin-1 protein, has been genetically linked to late-onset Alzheimer's.

  • Ubiquilin-1 protein levels are significantly decreased in the brains of late-onset Alzheimer's patients.

  • Diminished ubiquilin function may be a common denominator in AD progression.

  • Ubiquilin's interaction with amyloid precursor protein (APP) shows characteristics of a chaperone-client relationship, in which ubiquilin interacts transiently with APP to prevent irreversible aggregation and processing of APP that could lead to amyloid plaque formation. 21_3.inline-graphic-1.gif

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