About a year and a half ago, we tried to switch our patients from the brand name Clozaril to one of the generic brands of clozapine. Switches were made to the same dosage of the generic drug, with no titration period. Within two weeks, all of the patients seemed to be doing worse, with an increase of psychotic symptomatology. We immediately switched them back to brand-name Clozaril, and they all restabilized, fortunately without any hospitalizations. Since that time, we have left well enough alone and have not tried to switch to a generic again.