I was puzzled but respected his opinion. He patiently took me through the diagnostic manual, and I admitted that I would wake at 2 a.m. and stare at the ceiling. I did not enjoy eating anymore, had stopped a number of activities I used to enjoy, and had been that way for months. Of the three granddaddy antidepressants of that time, I started on imipramine and switched to desipramine in a few months for its less-sedating effect. Sure, psychotherapy was part of the treatment, and it was directed toward the proper use of the meds, changes that needed to be made in life, and other matters. I know from experience the benefit of antidepressants and how unpleasant the earlier ones were to take: dry mouth like you have never had before, constipation requiring regular enemas, and episodic sweating so profuse it runs down your face and soaks through your shirt. Noncompliance is very tempting. Nearly all the meds we prescribe are unpleasant, except the tranquilizers, which may be too much fun for some.