In the survey reported in the February 1 article titled "M.D.s Go Beyond Data in Choosing Medications," I believe it is no wonder that the private practitioners were exactly split over whether one antidepressant was better than others, because we, too, are confused by the few dozen academicians who are paid by the pharmaceutical industry to fly from one city to another and persuade us to make a certain brand of antidepressant our favorite while we consume a dinner of steak, salmon, wine, and salad. We defer to the message (as evidenced by the total eclipse of the TCAs) while being fully aware that there is no rhyme or reason (given our current stage of knowledge) as to why these sympathomimetic compounds work with one patient but not with another, although all of them work with a certain percentage of patients regardless of diagnosis—working best, of course, with those who have become unsympathetic to the general purpose of life (depressed).