On his return to Westboro he continued his interest in brain pathology and began to publish. His first publication in 1904 was a report on pernicious anemia in the insane, but after his return from Germany, his papers were on neuropathology. In 1907 the American Journal of Insanity (AJI), later the American Journal of Psychiatry, published his "Study of Neurofibrils in Dementia Paralytica, Dementia Seniles, Chronic Alcoholism." In 1911 AJI published his paper on plaques in the brain of aged people, which stated, "The plaques were the deposits in brain tissue of a chemical substance resulting from pathological metabolism of nervous elements." In a later paper he used the term "amyloid."