The findings by Lee and his group complement some that Guerry Peavy, Ph.D., an assistant clinical professor of psychiatry
at the University of California, San Diego, and colleagues reported in the September 1, 2007, Biological Psychiatry. Peavy and his colleagues found that nondemented seniors who possessed the e4 variant and who were exposed to prolonged stress
experienced memory impairment. This new study by Lee and colleagues, Peavy told Psychiatric News, "could help identify those at heightened risk for cognitive decline due to age, genetic status, and exposure to the chronic
stress of psychosocial hazards. Interventions to minimize the impact of the stress by reducing the hazards or by improving
coping strategies could help prevent or delay cognitive decline in those individuals who are most vulnerable."