However, data are available from brain autopsies of untreated patients done in the first half of the 20th century, prior to
the introduction of effective antipsychotic medications, said Lieberman. Those studies documented a variety of changes in
the brains of people with schizophrenia—aplasia, atrophy, hydrocephalus, and others, he noted. "So it is likely the disease
itself that contributes to those neuropathologies," he said.