Letters to the Editor
Narrowing the `Credibility Gap'
Psychiatric News
Volume 40 Number 16 page 28-28

I have been following the issue of black-box warnings for antidepressant medications since it came on the scene last year and would like to present some observations and concerns knowing that APA is actively involved in the safety and effectiveness of treatment for children and adolescents with depression as was described in the March 4 issue.

Last year the data being presented by the Food and Drug Administration involved a review of 4,400 subjects who were said to be "on" or" taking" antidepressant medication. What struck me at the time was that there was no reference to blood-level studies to prove that the subjects actually ingested the medication and/or developed any kind of blood level, that is, absorbed the medication and were not rapid metabolizers, for example. I would hope that APA and the American Academy of Child and Adolescent Psychiatry will pursue this particular aspect of the issue.

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