Adolescents with IBD report impaired health-related quality of life, poor self-esteem, fear of loss of control of bodily functions, and fear of pain and humiliation. Several studies have shown that adolescents with IBD have higher rates of depression compared with community controls and youth with other physical diseases. Our group has shown that depressed youth with IBD receiving CBT demonstrated improved depressive severity, improved functioning, and decreased medical utilization across two different pediatric gastroenterology settings. The CBT was based on a model developed by John Weisz and colleagues in 1997 known as Primary and Secondary Control Enhancement Training (PASCET). It postulates that depressive symptoms can be improved by teaching adolescents a more appropriate locus of control. The PASCET-CBT was modified to include (1) a focus on illness perception and coping, (2) hypnosis for abdominal pain and immune functioning, (3) education about the relationship between IBD and depression, and (4) emphasis on maladaptive illness behaviors (for example, disordered eating or medical nonadherence).