"Overall, it does seem that there is a small, but statistically significant increase in miscarriage with antidepressant use," Gail Robinson, M.D., a professor of psychiatry and director of the Women's Mental Health Program at the University of Toronto, told Psychiatric News. "[But] there is no information [in the report] as far as I could see about subjects' previous reproductive history, which may increase the risk. It is likewise not clear whether subjects receiving antidepressants actually took them; getting a prescription is not the same. And, most importantly, what is the risk of miscarriage in women with untreated depression? We know that there are a variety of negative outcomes associated with untreated depression in pregnancy, including pre-eclampsia, premature birth, and low birth weight, let alone suicide or attempts to self-abort. So depression itself confers a risk on pregnancy."