The work comes from the laboratory of Paul Greengard, Ph.D., winner of the 2000 Nobel Prize in Physiology or Medicine for
his discovery of how dopamine and other transmitters exert their actions in the nervous system. In the new report, Greengard
and his colleagues at the Laboratory of Molecular and Cellular Neuroscience at Rockefeller University proposed a "cytokine
hypothesis" of depression, saying that anti-inflammatory drugs achieve their therapeutic actions at least in part by regulation
of the formation of cytokines, those small cell-signaling protein molecules that are secreted by the glial cells of the nervous
system and by numerous cells of the immune system. The cytokines include the interleukins, lymphokines, and cell-signal molecules,
such as tumor-necrosis factor and the interferons, which trigger inflammation and respond to infections.