Alzheimer's patients taking antipsychotics showed steady, significant declines over time in most cognitive areas, including
in scores on the Mini-Mental State Examination (MMSE) and the cognitive subscale of the Alzheimer's Disease Assessment Scale.
Cognitive function declined more in patients receiving antipsychotics than in those given placebo on multiple cognitive measures,
including the MMSE, the cognitive subscale of the Brief Psychiatric Rating Scale, and a cognitive summary score summarizing
change on 18 cognitive tests.
Physicians prescribing antipsychotic medications for Alzheimer's patients with aggression and delusions should consider discontinuing
the drugs if patients do not respond.